ZFIN is now using GRCz12tu for Genomic Data
Gene
proza
- ID
- ZDB-GENE-061013-403
- Name
- protein Z, vitamin K-dependent plasma glycoprotein a
- Symbol
- proza Nomenclature History
- Previous Names
-
- wu:fj51g06
- zgc:152997 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation and proteolysis. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in Behcet's disease; brain ischemia; and stroke. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Protein Z deficiency] | 614024 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000294 | Gamma-carboxyglutamic acid-rich (GLA) domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Family | IPR012224 | Peptidase S1A, coagulation factor VII/IX/X/C/Z |
| Family | IPR050442 | Peptidase S1 family, coagulation factors |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR017857 | Coagulation factor-like, Gla domain superfamily |
| Homologous_superfamily | IPR035972 | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Coagulation factor-like, Gla domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Gamma-carboxyglutamic acid-rich (GLA) domain | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily | Peptidase S1A, coagulation factor VII/IX/X/C/Z | Peptidase S1 family, coagulation factors | Peptidase S1, PA clan | Serine proteases, trypsin domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q5S2 | InterPro | 426 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers